The company
The company
A revolucionary product that helps in the wound healing process.
Easy Application

ColZen® provides convenience of treatment to the patient, as it must be replaced on average every 72 hours or when needed.


ColZen® in contact with the wound becomes a transparent gel absorbed by the wound, which reduces the pain at the time of replenishment and permits the placement in the humid environment.


ColZen® molds easily to the contours of the wound and should be applied over the total area of ​​the wound, must cover its entire length, and may be cut when necessary.

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How to use:

It assists in bleeding control and it can be used in the treatment of infected wounds or wounds in which there is an increased risk of infection.



1- Hart J, Silcock D, Gunnigle S, Cullen B, Light ND, Watt PW: The role of oxidised regenerated cellulose/collagen in wound repair: effects in vitro on fibroblast biology and in vivo in a model of compromised healing. Int J Biochem Cell Biol 2002 (34): 1557-1570.

2- Monafo L. The use of topical cerium nitrate-silver sulfadiazine in major burn Injuries. 1983; Panminerva Medica - v. 25: 151-154.

3- Burkes S & McCleskey CS. The bacteriostatic activity of cerium, lanthanum, and thalium. J Bacteriology 1947. 54: 417-425.

4- Monafo WW, Tandon SN, Ayvazian VH, Tuchshmidt J, Skinner AM, Deitz F. Cerium nitrate: A new topical antiseptic for extensive burns. Surgery 1976; 80, p. 465-473.

5- Herberger K, Rustembach SJ, Grams L, Munter KC, Schafer E, Augustin M. Quality-of-care for leg ulcers in the metropolitan area of Hamburg – a communitybased study. J European Acad Dermatol 2012; 26: 495-502.

6- Frade MAC, Assis RVC, Coutinho-Netto J, Andrade TAM, Foss NT. Biomembrana vegetal na cicatrização de úlceras venosas crônicas. An Bras Dermatol 2012; 87 (1): 45-51.

7- Mendez MV, Raffeto JD, Phillips TJ, Menzonian JO, Park HY. The proliferative capacity of neonatal skin fibroblasts is reduced after exposure to venous ulcer wound fluid: A potential mechanism for senescence in venous ulcers. J Vasc Surg 1999; 30: 734-43.

8- Deveci et al: Effects of cerium nitrate bathing and prompt burn wound excision on Il-6 and TNFa Levels in Burned Rats. Burns 2000, 26:41-5.

To learn more about the product, please CONTACT US

Silvestre Labs® is a pharmaceutical company with 100% national capital, located in Biotechnology Park of Rio de Janeiro (BIO-RIO), with expertise in dermatological and cosmetic products.


Silvestre Labs is part of Axis Biotec Brasil Group. Led by professionals with over 20 years of experience, Axis Biotec´s mission is to translate scientific research into innovative products and services in the healthcare industry.


The vocation for innovation can be measured from the first product launched by Silvestre Labs®: DERMAZINE®, an antimicrobial broad-spectrum and healing agent, composed of silver sulfadiazine 1%, which molecular synthesis of the active substance was developed and manufactured by the company itself.


From the knowledge gained in the development process of  DERMAZINE®, new products with healing, antimicrobial, antiviral and immunomodulatory properties have been developed and launched such as COLZEN®, GINODERMAZINE®, DERMACERIUM® and DERMACERIUM HS GEL.

To know more about Silvestre Labs and its products, please visit

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Silvestre Labs

Química e Farmacêutica

Av. Carlos Chagar Filho, 791

Cidade Universitária - Ilha do Fundão

Rio de Janeiro - RJ

Zip Code: 21.941-904


+55 (21) 2142-7777


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